A Naturopath’s Take on the Most Talked-About Mitochondrial Hack
Lately, I’ve had more than a few clients ask me: “What do you think about methylene blue?” Some are already taking it and feeling sharper, more energised, more focused. Others are worried it’s just another hyped-up supplement with potential risks. And naturopaths? We seem to be split down the middle.
So I decided to write this post — not to hype it, and not to slam it — but to give you a balanced, functional health perspective on what methylene blue (MB) is, what it does, and whether it has a place in your protocol.
What Is Methylene Blue?
Originally developed as a textile dye, methylene blue has a long and fascinating medical history. It’s been used to treat malaria, urinary tract infections, and a condition called methemoglobinemia (where red blood cells can’t carry oxygen effectively).
In recent years, it’s gained attention as a possible nootropic (brain enhancer), mitochondrial booster, and even neuroprotective agent.
How It Works (In Simple Terms)
Methylene blue is unique because it can act as an alternative electron carrier in your mitochondria — the power plants inside your cells. If part of your electron transport chain isn’t working efficiently (as often happens with chronic fatigue, ageing, or inflammation), MB can bypass the block and help produce ATP (your body’s energy currency) more efficiently.
It’s also thought to:
- Activate Nrf2 (your body’s antioxidant defence system)
- Reduce oxidative stress
- Potentially stabilise tau proteins involved in neurodegeneration
Potential Benefits (Emerging Research)
While more robust human studies are needed, some of the potential benefits of MB may include:
- Improved memory and cognitive performance
- Increased cellular energy and stamina
- Support for mood and mental clarity
- Neuroprotective effects (early Alzheimer’s research is ongoing)
- Antimicrobial and antifungal properties
One small clinical trial even found MB improved short-term memory by 7% in healthy adults (based on fMRI imaging). [Rojas JC, 2012]
But… It’s Not for Everyone
Here’s where caution comes in. Just because it’s popular doesn’t mean it’s appropriate for everyone.
Potential risks and considerations:
- Can interact with SSRIs, SNRIs, or MAOIs — increasing the risk of serotonin syndrome
- May be contraindicated in pregnancy, breastfeeding, and G6PD deficiency
- High doses can be neurotoxic — the dose makes the medicine (or the poison)
- Quality and sourcing matter — industrial-grade MB is not suitable for human consumption
Who Might Benefit — and Who Should Avoid It
MB may be helpful for:
- Those with chronic fatigue, brain fog, or cognitive decline
- People recovering from viral infections (e.g. long COVID)
- Biohackers and high performers looking for a cognitive edge
It’s best avoided (or only used under supervision) in:
- People taking psychiatric medication
- Pregnant or breastfeeding women
- Anyone with impaired detoxification or on complex protocols
My Clinical Perspective
Personally, I haven’t trialled MB yet — but I’ve seen both enthusiasm and wariness within the health practitioner community. My stance?
It’s a tool — not a miracle. Like any tool, it can be misused. For the right person, in the right context, with proper dosing and monitoring, it may offer benefits. But it’s not something I’d recommend blindly.
If you’re already doing the work (nourishing your body, managing stress, supporting detox pathways), MB might be something to consider as a strategic next layer — not a shortcut.
What to Do If You’re Curious
- Start with the basics — no supplement can replace good sleep, diet, movement, and stress support.
- If you’re still curious, speak with a practitioner who can assess whether MB fits your picture.
- If you do try it, use a certified pharmaceutical grade product in very low doses, and avoid stacking it with other stimulating or serotonergic compounds.
Final Thoughts
Methylene blue isn’t magic, but it’s not snake oil either. Like many tools in functional medicine, its power lies in how and when it’s used.
If you’ve been curious — or already using it and wondering what it’s doing — I hope this gave you a grounded place to start. And as always, reach out if you want to discuss whether it’s right for you.
Want to explore more mitochondrial and brain-supportive options that are personalised to you? Book a consult or get in touch at hello@realfunctionalhealth.com.au.